An Expression of Interest (EOI) is a formal outreach from the Trial Innovation Network (TIN) to CTSA sites announcing a possible trial opportunity. The EOI is intended to provide CTSA sites, their affiliates, and partners, with opportunities to participate in potential trials through a TIN-developed outreach model. In this model, the TIN acts as the intermediary between the study-PI and the CTSA site. The TIN will work directly with the study team to develop a formal outreach which may include a request for sites to determine feasibility of study protocol and/or site budget, conduct an EHR-based Cohort Assessment to assess available recruitment populations, and identification of a local site investigator. Sites receiving the outreach request will have the opportunity to respond with the requested information or opt-out of the opportunity. The TIN may also provide support with further site assessment, selection, and activation of study sites.